Research Team Proves Bacteria-Killing Viruses Deploy Genetic Code-Switching to Deceive Hosts

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ORNL scientists proved the theory that bacteria-destroying viruses called bacteriophages use genetic code-switching to first infect and later overwhelm their hosts (credit:  Andy Sproles/ORNL, U.S. Dept. of Energy).
ORNL scientists proved the theory that bacteria-destroying viruses called bacteriophages use genetic code-switching to first infect and later overwhelm their hosts (credit: Andy Sproles/ORNL, U.S. Dept. of Energy).

April 3, 2023 | Originally published by Oak Ridge National Laboratory (ORNL) on March 15, 2023

Scientists at the U.S. Department of Energy’s Oak Ridge National Laboratory (ORNL) have confirmed that bacteria-killing viruses called bacteriophages deploy a sneaky tactic when targeting their hosts:  They use a standard genetic code when invading bacteria, then switch to an alternate code at later stages of infection.

Their study provides crucial information on the life cycle of phages. It could be a key step toward the development of new technologies such as therapeutics targeting human pathogens or of methods to control phage-bacterial interactions in applications ranging from plant production to carbon sequestration.

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