DNA as a Molecular Engineering Platform for Defense Applications


Presented: December 1, 2020 12:00 pm
Presented by: Dr. Steven Armentrout

DNA is more than a blueprint for living organisms. In the right hands, it can be used as a self-assembling, nanoscale building material with exquisite design properties. Over the past 15 years, DNA nanotechnology has emerged as one of the most promising platforms for the rational design of nanoscale devices. By “programming” DNA sequences to take advantage of DNA’s inherent complementarity (“A’s bind to T’s; C’s bind to G’s”), DNA can be made to precisely fold into complex shapes with rich functionality, giving nanoengineers precise control over many aspects of a design, such as size, shape, surface charge, surface hydrophobicity, choice of functional elements, and their spatial arrangement. Because a wide variety of molecular species can now be attached to DNA via a growing number of oligonucleotide chemistries, it can be used as a self-organizing substrate that enables a wide array of molecular species to be integrated into sophisticated macromolecular devices.

In this presentation, Dr. Steven Armentrout will describe how DNA nanotechnology is being used to create molecular devices, some less than 100nm in size, for defense applications ranging from nanosensors for pathogen detection to nanocarriers for delivery of drugs, genetic material, and cognitive boosting compounds. He will also show how computer-aided design (CAD) and virtual reality (VR) software, partially developed with DoD funding, is enabling nanoengineers to create, inspect, and edit nanoscale designs with ease and precision. Participants in this webinar will leave with an appreciation of the potential of DNA nanotechnology, its ability to address a variety of nanoengineering challenges, and an awareness of the many potential defense applications to which it can be applied.


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